View Count: 83 |  Publish Date: July 11, 2013
Toddler who received lab-made windpipe dies
CARLA K. JOHNSON, The Associated PressPosted: Monday, July 8, 2013, 3:44 PM
CHICAGO (AP) - A 2-year-old girl who was implanted with a windpipe grown from her own stem cells has died, three months after she became the youngest person to receive the experimental treatment.
Hannah Warren died Saturday at Childrens Hospital of Illinois in Peoria, hospital spokeswoman Shelli Dankoff said. Dr. Rick Pearl, one of three surgeons involved in the operation, told The Associated Press that Hannah died of lung complications following a second surgery, but that the new windpipe worked very well until the end.
Her family asked for privacy, but expressed their sorrow in a fundraising blog updated Sunday: She is a pioneer in stem-cell technology and her impact will reach all corners of our beautiful Earth. Her new trachea was performing well, but her lungs went from fairly good, to weak, to poor.
Hannahs treatment was part of an ongoing scientific effort to develop lab-grown tissues and organs. Similar methods have been used to grow bladders, urethras and last year a girl in Sweden got a lab-made vein using her own stem cells and a cadaver vein.
In Hannahs case, the stem cells came from her bone marrow. They were seeded in a lab onto a plastic scaffold, where it took a few days for them to multiply and create a new windpipe, which was implanted April 9.
Hannah was born in South Korea and traveled to Illinois for the surgery. A pediatric surgeon in Peoria had met Hannahs family while on a business trip to South Korea and helped connect them with Dr. Paolo Macchiarini, an Italian surgeon based in Sweden who pioneered the technique.
Hannahs parents, Darryl Warren and Lee Young-mi, had read about Macchiarinis success using stem-cell based tracheas, but they couldnt afford to pay for the operation at his center in Stockholm. Dr. Mark Holterman, the Illinois doctor, helped the family arrange to have the procedure at his hospital with Macchiarini leading the surgical team. Childrens Hospital waived the cost.
The hospital is part of OSF Saint Francis Medical Center, a Roman Catholic system that considers the operation part of its mission to provide charity care and a way to champion a type of stem-cell therapy that doesnt involve human embryos, the surgeons said in April. The Catholic church opposes using stem cells derived from human embryos in research or treatment.
Hannah had lived in a Seoul hospital all her short life before flying to the U.S. and her lungs werent strong, said Pearl, who is surgeon-in-chief at Childrens Hospital. She required a second surgery June 11 for a leak in her esophagus. Lung complications followed.
The girls family and her caregivers believe the knowledge gained from her surgery will benefit other patients.
We learned the trachea transplant worked. Thats very important and nobody should lose sight of that, Pearl said.
Hannah would have been 3 years old on Aug. 22.
We will forever miss her infectious personality and miraculous strength and spirit, her family wrote on their blog.
AP Medical Writer Lindsey Tanner contributed to this report.
AP Medical Writer Carla K. Johnson can be reached at
Regenerative Medicine: CARLA K. JOHNSONThe Associated Press #post2 .pw-icon.ra1-pw-icon-reddit {background: url() 0px 0px no-repeat !important;width: 60px !important;height: 20px !important;margin-right:8px;}#post2 .pw-icon.ra1-pw-icon-email {background: url() 0px 0px no-repeat !important;width: 71px !important;height: 28px !important;}

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