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View Count: 94 |  Publish Date: April 04, 2014
3D printing a new face, or liver, isn't that far off

Computerworld - NEW YORK -- Sixty years from now, well look back on todays 3D-printed tissue and organ technology and think its as primitive as the iron lung seems to us now.
Six decades out, replacing a liver or a kidney will likely be a routine procedure that involves harvesting some patients cells, growing them and then printing them across artificial scaffolding.
Dr. Anthony Atala, director of the Wake Forest Institute for Regenerative Medicine, spoke at the Inside 3D Printing Conference here about where the technology is today, and what hurdles it still must overcome.
The biggest hurdle is being able to 3D print supportive vascular structure so that tissue can receive the oxygen critical to its survival once its implanted into a patient.
Today, scientists can replicate tissue in small amounts beginning with the simplest: flat human skin tissue. Researchers have been able to create tubular blood vessels, and even parts of hollow organs of the body, such as the bladder. But, its the solid, hard organs, such as the liver and the kidney, that are more complex and require far more vascular support to recreate successfully.
Were working very hard to make sure we get there someday, Atala said.
Its not as insurmountable a goal as it may seem. For one, scientists dont need to replicate an entire organ. In fact, up to 90% of an organ can fail before it seriously affects the health of a patient, Atala said.
Imagine youre playing tennis one weekend and you get chest pains. You go and get an x-ray and they find 90% of youre your heart vessel is occluded. The fact is you never had chest pain when your heart vessel was 80% occluded, he said. Its the same thing with kidneys. You dont get into kidney failure until about 90% of your kidney is gone. So you have to burn 90% of your reserve before you get in trouble.
The current strategy of bioengineers is to create enough tissue to boost an organ thats failing while not completely replacing it, Atala said
Typically, the maximum distance between tissue and the vascular structures that support them is 3mm. That means that for every 3mm of tissue, physicians will have to be able to construct capillaries to support them.
Today, 3D bioprinting constructs a series of tissue held up by artificial scaffolding, like the iron beams in a building. First a layer of scaffolding is laid down, and then a layer of cells is laid down on top of that.
In the past, scientists have had to separately create the scaffolding, and then coat it with the living cells. That not only takes longer to complete, but it also places the living cells in danger of dying before they can even be implanted.
3D printing allows the scaffolding and living tissue to be printed together.
In order to construct veins and capillaries, they first print out a tubular construct made of dis-solvable material; they then coat the outside of that tube with muscle cells and the inside with venous barrier cells. A heart valve can be constructed in the same way; first by using dis-solvable scaffolding followed by outer muscular cells and interior barrier cells.

Keywords:
 cells   construct   create   kidney   organ   print   scaffolding   support   tissue   your heart vessel   Atala 

Picture Keywords
 cells   construct   create   kidney   organ   print   scaffolding   support   tissue   your heart vessel   Atala 
Time: 22:20  |  News Code: 394609  |  Site: computerworld
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